Protein Hydrolysate of Green Peas Bromelain Attenuates Kidney Fibrosis in Cisplatin-Induced Nephrotoxicity Rats: Emphasis on Anti-Inflammatory Activities

Massive tubule fibrosis is a histopathology hallmark of chronic renal failure (CRF). The previous study protein hydrolysate green pea (Pisum sativum) bromelain (PHGPB) showed promising results as an antifibrosis in glucose-induced mesangial culture cells, by decreasing their TGF-? levels. In this experiment the anti-inflammatory, anti-fibrotic effect PHGPB Cisplatin-induced (CRF) rats was measured. purpose to evaluate anti-inflammatory and rats. Five groups consisted five rats: negative control, Cisplatin three Cisplatin+PHGPB (dose 100, 200, 400 mg/kg BW/day) treated for 56 days. examined parameters are Beta-2-microglobulin (?2MG), hs-CRP, histopathological observations Masson's trichrome stain, IHC. level ?2MG hs-CRP group lowered highly different from control (p<0.05) depending on doses. histopathology, BW less no significant difference with Masson trichome staining. While IHC treatment slightly ameliorated expression intensity values convincingly. conclusion, can relieve kidney cisplatin-induced nephrotoxicity Emphasis activities.